[Freeciv] Infusion Pump for Biomedical Research

["Med-e-Cell" <news2@xxxxxxxxxxxx>]

                Infu-Disk™ Infusion Pumps for Biomedical Research....
        Accurate, Easy to Use, Easy to Attach, Ambulatory                       
                                                                                
                                                
                                                                                
                                        
                                                                                
                                                                                
                        
                                                                Idun 
Pharmaceuticals Compares a Harvard Apparatus       PHD2000 Syringe Pump         
           to Infu-Disk™
        "Infu-Disk™ vs. Harvard Apparatus PHD Pumps 2000" by 
Lisa       Adams, Tammi Howard, Amos Jarrette, Pauline Yeo, PhD. Idun 
Pharmaceuticals (www.idun.com)

        "The Med-e-Cell Infu-Disk™   was tested to see whether they 
delivered compound as    well as the Harvard PHD2000 pump

        Materials and Methods:
        Male Spontaneously Hypertensive rats weighing 250-300 g were cannulated 
(heparinized PE50 tubing) via the left femoral vein and the cannula is threaded 
subcutaneouly up the back to the        dorsal nape of the neck and secured.  
Twenty four       hours later cannulated rats (n=3/group) were attached to      
  either a Harvard PHD2000 pump (settings=0.43 mL/hr, 10cc        syringe=14.5 
mm ID, infusion target 10.0 mL) with a rat jacket and tethered to a bucket or 
to a Med-e-Cell Infu-DiskTM  (premanufactured at 0.43 mL/hr) with a 
Harvard/Covance  jacket.  Compound was administered as a loading bolus dose 
followed by infusion for 24 hours.  Serum samples    were taken at 4 and 24 
hours post administration and analyzed   by LC/MS.

        Results:
        Med-e-Cell Infu-Disk™ [pumps]     delivered comparable serum 
concentrations of compound as        Harvard Apparatus PHD2000 pumps and gave 
the rat more   freedom of movement".

        Med-e-Cell isn't suggesting that Infu-Disk™ is a  replacement for 
high accuracy syringe pumps but in many cases it can be a much better solution 
than a syringe or        peristaltic pump.

        Infu-Disk™ Use Growing
        Merck, Pfizer, Bristol Myers-Squibb, Covance, Idun Pharmaceuticals,     
Gwathmey, Oncologic, Vertex Pharmaceuticals are some of the growing     numbers 
of companies and research institutions using Infu-Disk™

        The Infu-Disk™ family of infusion pumps is now being used by many 
of the largest and most respected companies and research        institutions 
around the world.  In many situations      Infu-Disk™ is replacing 
syringe pumps, peristalic and other       electromechanical pumps.  Since 
Infu-Disk™allows for ambulatory infusion the need for a tether is 
eliminated.     The animal does not need to be isolated or restrained   and can 
be placed in a comfortable environment.         Stress induced by tethered 
systems is no longer a factor        in the experimental data.

        For Infu-Disk™ performance specifications, see    
www.medecell.com/products/data_sheet.htm

        You can order Infu-Disk™ online at        
www.medecell.com/products.htm   or by phone at 858-552-0781.                    
                                        Breakthrough Cancer Technology Uses 
Med-e-Cell Pumps
                        Oncologic is developing treatment for inoperable solid 
cancers

                                Oncologic, Inc. is a two-year-old San Francisco 
Bay Area biotechnology company with     headquarters in Richmond, CA.  
Oncologic is     developing a proprietary technology for the treatment of       
 inoperable solid cancers (breast, prostate, colon, lung,        etc.) which 
simulates the 95%-curative treatment of     thyroid cancer.  It has been 
described by       scientists as ?the first real chance for consistent     
cures.?  Oncologic is now raising a Series B    investment round of up to $5 
million ? for more information please visit        www.oncologic.net.

                According to Dr. George Mayers, Director of Biological Research 
at Oncologic and former Chair of the Department of Immunology at Roswell Park   
Cancer Center, ?The convenient Med-e-Cell Infu-disk     pumps enable us to 
deliver to rats a controlled,        continuous intravenous infusion of our 
proprietary      compounds, thereby increasing targeting specificity and tumor 
concentrations versus a single injection.?

        "We use the Med-e-Cell pumps with special       CDF rats.  At Charles 
River Labs, the rats      receive a femoral vein catheterization that exits     
  just behind the animal?s head.  The     Med-e-Cell pump is secured via a 
backpack harness       that does not interfere with the animal?s freedom       
of movement and the pump dispenses our agents into      the catheter opening."

                                Merck Study Ranks Post-Op Analgesics Delivery 
Methods
                                Epidural administration and continuous infusion 
using   the Infu-Disk™ are the top two "best methods" for delivery        
of postoperative analgesics

                        A study conducted by Merck, "Implantable   
Osmotic, Preset and Programmable Infusion Pumps as Novel        Methods for 
Delivery of Postoperative Analgesics in     Dogs"*, found continuous 
infusion using Infu-Disk™   to be the best method just behind epidural    
  administration.  The method was described as    "Very Good" when 
compared to a high cost      programmable and an implantable pump.

        Advantages were stated as "Easy to set up and maintain"       
and "Easy to remove and discard".     Although epidural 
administration was ranked as the most effective, the method is 
"technically      difficult" and does not maintain a steady level of 
drug in the blood stream beyond 2 to 4 hours.   Infu-Disk™ can deliver 5 
mL or 10 mL continuously at      rates from 0.03 mL/hr to 4.0 mL/hr.

*Poster presentation given by David B. Gilberto,D.V.M. et al., 1999.            
                                                
                                                                                
                                                                                
                                                                
                                                                                
                                                        5 mL Infu-Disk™
                - $41.00 std / $44.00 custom
        - Delivery Rates: 0.03 to 1 mL/hr
        - Accuracy better than ±10%
        - Available sterile or non-sterile
        - Connector: male luer lock                                             
                Accurate, continuous fluid delivery from a 5 mL reservoir at 
rates from 0.03 to 1.0 mL/hr.
        View Performance Specification Data
        Exceptionally easy to use and fill.
        View Use Instructions                                                   
                
                                                                                
                                                                        
                                                                                
                                                        10 mL Infu-Disk™
                - $41.00 std / $44.00 custom
        - Delivery Rates: 0.03 to 0.5 mL/hr
        - Accuracy better than ±10%
        - Available sterile or non-sterile
        - Connector: male luer lock                                             
                Accurate, continuous fluid delivery from a 10 mL        
reservoir at rates from 0.03 to 0.5 mL/hr.
        View Performance Specification Data
        Exceptionally easy to use and fill.
        View Use Instructions                                                   
                
                                                                                
                                                                        
                                                                                
                                                                                
10 mL Infu-Disk™ HF
                - $41.00 std / $44.00 custom
        - Delivery Rates: 0.5 to 4.0 mL/hr
        - Accuracy better than ±10%
        - Available sterile or non-sterile
        - Connector: male luer lock                                             
                Accurate, continuous fluid delivery from a 10 mL        
reservoir at rates from 0.5 and 4.0 mL/hr.
        View Performance Specification Data
        Exceptionally easy to use and fill.
        View Use Instructions                                                   
                
                                                                                
                                                                                
        
                         
                                        All Med-e-Cell products including 
Infu-Disk™ are based on its patented                            Prime 
Mover™ technology.  Prime Mover™ is an efficient,                   
          low power, cost effective means to move fluids, move and generate 
gases, actuate devices, generate                              power, to name a 
few.  Please visit Med-e-Cell's technology licensing                           
pages to find out more about using Prime Mover™ in your product design.   
                                                                
                                                                                
                                                                        
                                        For questions or to order: 
(858)552-0781                                                                   
             
                Visit www.medecell.com for information
                on this exciting new line of infusion pumps.                    
                                                                                
                                                        
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